ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury
نویسندگان
چکیده
منابع مشابه
ROS‐responsive drug delivery systems
Reactive oxygen species (ROS) play an important role in signal transduction and metabolism. Over-produced ROS in cells or tissues, however, often leads to oxidation stress that has implications in a series of diseases including cancer, aging, atherosclerosis and inflammation. Driven by the need for on-demand drug delivery and fuelled by recent development of ROS-responsive materials and nanomed...
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PURPOSE Nanoparticles (NPs) that target bone tissue were developed using poly(lactic-co-glycolic acid) (PLGA) copolymers and tetracycline (TC)-based bone-targeting moieties. These NPs are expected to enable the transport of drugs, such as simvastatin (SIM), for the treatment of osteoporosis. METHODS The molecular structures of TC-PLGA were validated by (1)H-NMR, and the SIM-loaded NPs were pr...
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ژورنال
عنوان ژورنال: Theranostics
سال: 2020
ISSN: 1838-7640
DOI: 10.7150/thno.40395